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A close review of published case reports reveals a consistent clinical phenotype in the rare events that do occur: recent dose escalation, severe obesity, and deep sedation without airway protection are often present

(5) Some authors have suggested that there may be an increased risk of paradoxical agitation when using benzodiazepines in the treatment of serotonin syndrome.(23117910) This isnt a problem with dexmedetomidine

Journal Reference Degorge M.F., Mertz S., Gailer J

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Multiple dose levels (1, 4, 8, 12 mg) were tested in Phase 2, with the Phase 3 dose selection to be refined based on efficacy-tolerability balance