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Common adverse reactions to Wegovy include nausea (reported in up to 44% of patients during clinical trials according to the MHRA SmPC), vomiting, diarrhoea, constipation, and abdominal discomfort

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Ongoing studies are evaluating cardiovascular outcomes with tirzepatide in populations with overweight/obesity and T2D (SURPASS-CVOT) and in those with obesity but without diabetes (SURMOUNT-MMO) [28, 29]

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Patients should be counseled never to administer extra doses to make up for missed doses, as this could increase the risk of adverse effects without providing additional therapeutic benefit