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One article notes that DSIP levels show a diurnal variation and correlate with the bodys circadian rhythms, sleep-wake cycle and circadian rhythms

Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system

R., Baber, R., Panay, N., Bitzer, J., Perez, S

Some users describe the experience as anhedonia, or an inability to feel pleasure, sometimes dubbed online as the Ozempic personality. Patients report losing interest in hobbies, social activities and even food itself, describing a persistent sense of emotional flatness or indifference

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