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CGRP released from cutaneous trigeminal nerve fibers and acts on surrounding Schwann cells, perpetuating cutaneous allodynia through a cyclic AMP-dependent mechanism that generates NO in endosomes (31)

Both medication classes can cause gastrointestinal side effects, and taking them together might intensify symptoms such as nausea, vomiting, or diarrhea

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In contrast, baseline HbA1c and external eating scores were independently associated with greater reductions in body weight at 12 months ( Table 4 )