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Both neuronal populations are also subject to modulation by 5-HT, orexin, and NE, which alter membrane excitability by adjusting threshold potentials and after-depolarization amplitudes according to the behavioral state (Tanaka et al., 2020)

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The long-term clinical benefit should be established in the future.Whether or not subclinical hypothyroidism should be treated is still under debate (see Chapter 9.10 SUBCLINICAL HYPOTHYROIDISM)

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