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Andersen, P

Early leptin response to a palatable diet predicts dietary obesity in rats: key role of melanocortin-4 receptors in the ventromedial hypothalamic nucleus

Only in very limited circumstances, such as: BMI remains marginally above 22 kg/m Significant history of obesity-related disease Clear risk of rapid weight regain However: Treatment below BMI 22 kg/m is not routine Continuation is never guaranteed Each case is reviewed individually What Happens When You Stop GLP-1 Medication

Theres also little evidence about whats in them. The NHS even puts a very prominent warning on its site saying: As does Cancer Research UK: Melanotan nasal sprays and injections are not safe to use

That is a meaningful standalone number for a compound that most people only ever discuss as an add-on