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Metformin was dosed twice daily (one tablet of Glucophage 500 mg) in two periods of 3.5 days before and with semaglutide, to obtain steady-state conditions and minimise the potential of within-subject variation in metformin bioavailability [20]

Many people get significant fluids from meals, so reduced food intake means actively drinking more water

In the analysis, the researchers assessed the outcomes of 26 randomized controlled trials comprising 15,491 participants with overweight or obesity

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