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In the present cohort of adolescents, we found that females exhibited a higher cortisol/11-deoxycortisol ratio than males, a difference that mediated in part the higher levels of internalizing symptoms observed in females, suggesting a causal effect of HPA-axis function on internalizing symptoms

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Changes in insulin regimen including, strength, manufacturer, type, injection site or method of administration may result in the need for a change in insulin dose or an adjustment in concomitant drugs

Aunque transitorios en la mayora de los casos, estos sntomas pueden ser molestos, lo que lleva a algunos pacientes a interrumpir el tratamiento prematuramente