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Risk factors associated with WD cirrhosis Age at diagnosis had 89.5% sensitivity, 69.0% specificity, and an AUC of 0.802 (95% CI: 0.6790.926) for diagnosing WD cirrhosis, with a cut-off value of 22 years old

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Recombinant human PCSK9 with an N-terminal Avi-tag (in-house) was biotinylated using the biotin ligase BirA (Avidity LLC) as per the manufacturers instructions

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The lessons learned about scale-up complexity, supply variability, and talent management will influence how the industry tackles other therapeutic waves in the future