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Moreover, mitochondrial damage elevates ROS levels (380), which can in turn damage mtDNA and proteins that may be involved in the electron transport chain (ETC), resulting in lowered ATP production and decreased energy levels (381)

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doi: 10.3389/fimmu.2022.918160 Received 12 April 2022 Accepted 15 June 2022 Published 07 July 2022 Volume 13 - 2022 Edited by Xi Tao, China Pharmaceutical University, China Reviewed by Bhrugu J

Individuals with active malignancy, uncontrolled serious illness, pregnancy, breastfeeding, or complex immune or coagulation disorders are commonly considered poor candidates and require alternative strategies