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Individuals with pernicious anemia, characterized by a lack of intrinsic factor, are also particularly susceptible

It is particularly common in individuals with certain risk factors, including those who have undergone gastric or small intestine resections, have inflammatory bowel disease, use metformin or proton pump inhibitors, follow a vegan diet, or are older than 75 years

While found throughout the body, its more prominent in the liver and in fat cells