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In their systematic review, Athanasiadis et al

The exact BMI thresholds the FDA sets for GLP-1 medications The FDA approval language is remarkably consistent across GLP-1 medications approved for weight management

GLP-1 receptor agonist (RA) medications work by mimicking natural hormones that promote feelings of fullness, helping to reduce calorie intake

In the VALOR trial, brepocitinib 30 mg demonstrated clinically meaningful and statistically significant improvement compared with placebo on the total improvement score (TIS), the primary endpoint