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The absence of drug affinity complex modification results in a shorter receptor interaction window, allowing for transient activation that aligns with pulsatile signaling models

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On more stable days, you can incorporate strength training or slightly longer walks to support insulin sensitivity

This does not invalidate the findings but adds a potential source of bias Single-blind only: While the investigator assessing photos was blinded, patients knew whether they received the active serum or saline, which could influence self-reported satisfaction scores No long-term follow-up: The study ended at 6 months