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Russell-Jones D, Cuddihy RM, Hanefeld M, Kumar A, Gonzlez JG, Chan M, et al

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By correctly phenotyping irAEs and understanding the varied presentations and natural history, we can begin to develop a framework to distinguish between AEs associated with conventional chemotherapy or targeted therapy and immunotherapy

Cells involved in repair (fibroblasts, endothelial cells, muscle cells) appear to respond through signaling changes that support migration, collagen organization, and local tissue rebuilding