mode of action of semaglutide Spotlight on the Mechanism Mechanism of semaglutide for management

Pediatrics , 155(4), e2024068120

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Despite the substantial improvements in body weight and glucose control elicited by GLP-1R agonists, patient uptake and compliance are challenged by frequent gastrointestinal adverse events (GI AEs), including nausea and vomiting, that necessitate careful dose titration regimens to achieve efficacious exposure (14)

It is essential that any decision to use both medicines is made with full clinical oversight, as each patient's circumstances differ significantly