flow trial semaglutide kidney outcomes nejm 2024 hazard ratio 0.76 in Patients with Obesity-Related Heart Failure and Type 2 Diabetes Semaglutides Are Poised to Remake

S6 show that both GLP-1RA and SGLT-2 inhibitors were associated with a lower risk (13% and 14%, respectively) as compared with placebo and DPP-4 inhibitors (11% and 12%, respectively), although the difference in risks was significant for SGLT-2 vs DPP-4 inhibitors only

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The synergetic effect of activating these three receptors makes the medication highly effective for weight reduction

Todays letter will clarify those differences based on the data and mechanisms