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Plasma levels drop significantly with age

8g-j), which was markedly attenuated on days 7 and 9

Balanced cohorts (n=169,630 each) were created using 1:1 propensity score matching

We established an FP competition assay to biochemically validate displacement of the TIN2 peptide by the compounds and further showed that compound 40 , identified as one of the most potent analogues amongst the compounds tested, evicted full-length TRF1 from the shelterin complex by disrupting the TRF1 TRFH :TIN2 TBM interaction

If validated, this triad could redefine PCOS management as a precision nutraceutical strategy, shifting therapy from fragmented symptom control to restoration of redox-endocrine homeostasis