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The study found that both drug combinations resulted in significant reductions in tinnitus severity, as measured by the Tinnitus Functional Index (TFI), compared to placebo, demonstrating their potential efficacy in tinnitus management

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Despite the substantial conformational dynamics when bound to AMY 3 R, Cagri maintains the bypass conformation across the motions, likely arising from the consistent TMD and linker interactions between RAMP3 and CTR that enable robust engagement of residues within the Cagri bypass motif