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Understanding how these two agents might work together could inform dietary strategies for patients receiving GLP-1 receptor agonist treatment, though it is important to note that research in this area remains in relatively early stages

Among them, the development of glucagon-like peptide-1 (GLP-1) receptor agonists and the development of GLP-1 receptor agonists ranked first among them

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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury (Zhao et al., 2025c)

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