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These premixes were then incorporated into the experimental diets to achieve dietary TAs concentrations of 0.00 (basal diet), 80, 160, 240, 320, and 400 mg/kg, respectively

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Retatrutide is dosed once weekly by subcutaneous injection, titrated in 4-week steps from a 2 mg start through 4, 8 and 12 mg, with 12 mg being the maximum dose tested in the 2023 NEJM Phase 2 trial (24.2% mean weight loss at 48 weeks) [5][2]

[12] What we have done is take a lifestyle-driven metabolic problem and tried to solve it with a pharmaceutical appetite suppressant

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