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A 2024 study found that GLP-1 peptides directly inhibit the TRPV1 pain receptor, which is sometimes called the chilli pepper receptor because its the one that responds to capsaicin [6]

The drug is being developed by Eli Lilly and Company, the same pharmaceutical manufacturer behind tirzepatide (Mounjaro), which has received MHRA approval in the UK for type 2 diabetes and, more recently, for weight management

Patients with proliferative retinopathy or maculopathy resulting in active treatment were excluded from the PIONEER 6 CVOT, in which no apparent imbalance was observed between oral semaglutide and placebo in the AE reporting of diabetic retinopathy over 16 months (66)

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