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These results reveal predispositions in peptide metabolism and appetite regulation but do not predict exact medication response or guarantee specific weight loss outcomes

placebo across all the randomized controlled trials

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But their effects last only as long as youre taking the drug

In this study, the central mechanism underlying TAM lipid metabolic reprogramming relies on NP-mediated targeted siCB-2 delivery to TAMs, which silences CB-2 expression, disrupts the 2-AG signaling cascade, and redirects TAM polarization toward the pro-inflammatory M1 phenotype, ultimately restoring anti-tumor immune responses