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Sometimes pain comes down to technique - injecting too slowly or at the wrong angle can increase discomfort

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In this situation, it can be challenging to demonstrate B12 deficiency even when there are typical symptoms (including neuropathy-like paraesthesia and numbness), as serum B12 concentrations may be just within, or sometimes above, the normal range due to the oral supplementation

4 If vitamin B12 is lyophilized, such as in some forms of methylcobalamin, the medication should be refrigerated after mixing

Skin and subcutaneous adipose layer thickness in adults with diabetes at sites used for insulin injections: implications for needle length recommendations Shorter needles are also less painful, because they penetrate less tissue: The needle lengths that were once recommended for SC injection (for adults, 8 mm