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When its function is disrupted, it results in ER stress, which triggers a cellular defense mechanism known as the unfolded protein response (UPR) [46]

This artificially synthesized analog of alpha-melanocyte-stimulating hormone (-MSH) precisely mimics the naturally produced melanocyte-stimulating hormone in the human body, directly activating the MC1 receptor in melanocytes, triggering an increase in tyrosinase activity, and accelerating the generation and transport of melanin