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Effector T cells that secrete GM-CSF [8], Th17 cells that produce glutamate [9], CXCR4 + T cells with GM-CSF [10], regulatory T cells (Tregs) [11], CD8 + T lymphocytes [12], and regulatory B cells (B regs) that secrete IL-10 and IL-35 are only a few newly identified immune cells in MS [13, 14]

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On the other hand, the concept of non-genomic or cytoplasmic response was introduced in 1967, when Szego and Davis observed an increase in cyclic adenosine monophosphate (cAMP) in the MCF-7 breast cancer cell line pretreated with estrogens (Szego and Davis, 1967)