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In glutathione target genes-heart failure network analysis, 7 targets were identified, including tumor necrosis factor, vascular endothelial growth factor A, fibronectin 1, serine proteinase inhibitor 1, insulin-like growth factor binding protein 3, matrix metalloproteinase-1 and liquid oxygen, with serine proteinase inhibitor 1, insulin-like growth factor binding protein 3, fibronectin 1 and liquid oxygen significantly over expressed in heart failure

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Cardiometabolic Improvements Reduction in waist circumference and visceral fat mass Improved fasting blood glucose and insulin sensitivity markers Favorable effects on systolic blood pressure Reduction in triglycerides and improvement in lipid profiles Potential cardioprotective effects under ongoing investigation Tolerability Profile Cagrilintide 10mg has shown a manageable safety and tolerability profile in clinical settings