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Musculoskeletal symptoms: Joint pain (arthralgia), muscle aches, peripheral edema (mild swelling) [9]

Urgent same-day assessment or emergency care is warranted if: Fever above 38C with rigors or shaking chills Loin pain or flank tenderness suggesting upper urinary tract involvement Severe systemic symptoms confusion, severe malaise, or vomiting Inability to tolerate oral fluids due to persistent vomiting Visible haematuria with clots indicating significant bleeding These features may indicate pyelonephritis or complicated UTI requiring urgent medical evaluation and possible hospital admission for intravenous antibiotics

The drug also helped participants with weight loss, improved liver markers, and boosted overall heart health with no major differences in serious side effects compared to those not taking it

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ICRS classification of cartilage damage: Since cartilage does not have its own blood supply, it is supplied via the synovial fluid and the subchondral bone