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Don Colbert MD

When cytoplasmic catecholamine concentrations rise to levels that threaten to saturate both VMAT2 sequestration and mitochondrial monoamine oxidase (MAO) degradation pathways, the reversal of plasma membrane transporters provides a vital escape route (Underhill et al., 2021)

Recent studies have revealed that CAF-derived exosomes in the TME can facilitate communication between tumor and stromal cells and contribute significantly to tumor progression [147,148]

View in: Pubmed Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade

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