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The expression of ERS genes caspase-12 , ATF4 , and CHOP in MCAO rats increases, and the levels of apoptosis increase

A meta-analysis of 22 studies found that Alzheimers patients exhibit reduced peripheral TRP, increased KYN/TRP ratio, decreased cerebrospinal fluid 3-HK, and opposing KYNA changes in brain versus blood [250]

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More specifically, the 10 residue sequence of the cleavage site at the nsp13/14 junction shown in Figure 2A, with the greatest overall similarity to the GPX1 active site sequence, is 100% identical in the 2003 and 2019 SARS coronaviruses (Figure S1)