Metal ions influx is a double edged sword for the pathogenesis of Alzheimers disease
For example, melasma (a skin condition that causes dark patches on the skin due to hormones) alone affects nearly five million people in the United States, according to the Journal of Community Hospital Internal Medicine Perspectives

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PMID: 41747719 Carbohydr Polym Hijacking the hyaluronan assisted iron endocytosis to promote the ferroptosis in anticancer photodynamic therapy
Tyrosinases hydroxylate monophenols to form ortho -diphenols (monophenolase activity) and subsequently oxidize the o -diphenols to o -quinones (diphenolase activity)