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However, semaglutide has cardiovascular outcome data (the SELECT trial) that tirzepatide does not yet have from a completed dedicated outcomes trial

The first week is primarily an adjustment period, and the full therapeutic benefits of semaglutideincluding sustained weight loss and improved glycemic controldevelop over months, not days

semaglutide Month 13: Faster initial fat loss, avg 23 lbs/week Month 36: Significant body composition improvement 7288 weeks: Average 2025% total body weight reduction SURMOUNT-5: Tirzepatide confirmed superior to semaglutide head-to-head (2025)

Here are some tips to reduce nausea and the risk of vomiting on Ozempic: Eat smaller meals Eat slowly and mindfully You might need to include snacks in-between your three main meals to ensure youre eating enough Stay hydrated Avoid foods that previously made you nauseous Record a food diary of foods you notice trigger symptoms Eat simple meals based on a good source of protein, complex carbohydrates, fruit or vegetables, and some fat Dont lie down after your meal, maybe opt for a short walk Avoid eating too close to bedtime Speak to your doctor or prescribing physician if symptoms persist or become too uncomfortable 2) Constipation and diarrhoea Constipation occurs in around 25% of participants taking semaglutide