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Whereas sporadic and NF1-associated malignant peripheral nerve sheath tumors showed a comparable frequency of loss of H3K27 trimethylation (72% vs 71% respectively), all radiation-associated malignant peripheral nerve sheath tumors ( n =4) exhibited loss of H3K27me3 expression

This demonstrated that the -MSH-MC1R signaling pathway induces melanin production predominantly by elevating intracellular cAMP levels, and the inhibition of which can exert inhibitory effects on melanogenesis

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