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Bastianini et al., 2021), and as these are also partially present in HnB mainstream products, the present study aimed to investigate in a rat model the effects of HnB tobacco exposure on testicular function by focusing the expression of pro-inflammatory NF-B target genes and oxidative stress markers, including those associated with DNA damage

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These abnormalities can cause decreased production of 5-methyltetrahydrofolate, impair the production of folate cycle metabolites and decrease folate transport across the bloodbrain barrier and into neurons