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Similar results were obtained in GRK3 KO mice, when morphine tolerance to analgesia was unchanged whereas tolerance to high efficacy agonists, such as fentanyl or U50,488, was reduced (Terman et al., 2004

Overall, current evidence suggests that selenium supplementation may hold greater potential in individuals with low selenium status, whereas its generalized use remains to be validated in larger and more rigorously designed trials

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Many of this studys subjects also had ligament sprains and tendon issues, which often heal on their own over time, so its unclear if these improvements were due to the peptide or just the passage of time (the study had no control group)