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Nat Rev Cancer 6 : 3851 Carducci M et al

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In the OASIS 4 Phase 3 trial, it delivered 16.6% mean weight loss at 64 weeks

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In all cases, fecal and plasma histidine and ImP monitoring, and metagenomics or TOPOSCORE (to follow bacterial histidine consumers or producers) should be conducted to identify subsets of patients who could benefit from this food supplement

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doi: 10.1210/jcem-64-1-190 20 ErbilDErenCYDemirelCKucukerMUSolarogluIEserHY

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