Maintaining quality sleep, managing stress, building a balanced diet, and limiting factors that increase oxidative stress are crucial foundations for a more effective functioning of the endogenous antioxidant system
Genetic predisposition also plays a role
Beyond direct antioxidant activity, glutathione functions through several enzymatic systems central to detoxification and redox control, including glutathione-S-transferases for conjugation reactions, glyoxylases, glutathione peroxidases and peroxiredoxins for peroxide reduction, and glutaredoxins for thiol-disulfide exchange
The biological role of glutathione and glutathione S-transferases in oxidative stress Numerous studies have shown that in order to avoid prolonged exposure to ROS produced during oxidative stress, the body has a very efficient antioxidant defense system
Therefore, GABA, EAAT2, and KCC2 were the most reliable biomarkers for distinguishing treatment effects