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Although some of these findings are conflicting, many components of the IGF-1 system are known to be altered during BrCa establishment and progression [9,16,18]

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Since diacylglycerol acyltransferase 1 (DGAT1) can increase the conversion of DAG into triacylglycerol (TAG), 171 DGAT1 overexpression could decrease DAG levels and improve insulin sensitivity partially attenuating the fat-induced activation of DAG-responsive PKCs

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