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When You Might Need Higher B12 Doses While the standard RNI of 1.5 mcg per day suffices for most healthy adults, certain medical conditions, dietary patterns, and medications can substantially increase B12 requirements or impair absorption, necessitating higher therapeutic doses under medical supervision

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Removing the device too quickly can leave medication on the skin or create uncertainty about whether the dose was delivered

There is limited co-expression of GIPR and GLP-1R (88)