who is semaglutide good for Semaglutide: Double-edged Sword with Risks and Benefits Oral vs Injectable Semaglutide in

10 Incretin agents, including dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1 RA), improve glucose control through several mechanisms, including the increase of glucose-dependent insulin secretion, decrease of gastric emptying, and reduction of postprandial glucagon secretion

In this perspective, the qualitative goal of maintaining LBM is increasingly recognised as being as important as quantitative weight loss [23]

Rodriguez PJ et al

The majority of patients were commenced on semaglutide for weight regain ( n = 103, (64.8%)) and weight regain was also the most common reason for commencing therapy in both primary and revisional cases

however, excluding PIONEER 6 enhanced benefit and narrowed the CI, indicating greater robustness post-exclusion