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Patients should be advised to report to the physician immediately any of the following: numbness or tingling in the fingers and toes, muscle pain in the arms and legs, weakness in the legs, pain in the chest, temporary speeding or slowing of the heart rate, swelling, or itching

Additionally, iron ions binding to transferrin significantly reduce its potential toxicity, while unbound free iron ions are the main factor causing tissue cell damage (46, 47)

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There are several possible hazards associated with this therapy, though the data on its advantages is scarce