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Additionally, there are other systems independent of GPX4 that regulate ferroptosis, such as ferroptosis suppressor protein 1 (FSP1)/ubiquinone (CoQ10) [23], dihydroorotate dehydrogenase (DHODH) [24], GTP cyclohydrolase-1 (GCH1)/tetrahydrobiopterin (BH4) [25], and amino acid oxidase interleukin-4-induced-1/indole-3-pyruvate [26]

[DOI] [PubMed] [Google Scholar] 18.Flagg EW, Coates RJ, Jones DP, Byers TE, Greenberg RS, Gridley G et al

FIGURE 3 4 Robust synergistic therapy against cancer 4.1 Sensitized chemotherapy As a chemotherapeutic agent, platinum is one of the most widely used metal-based anticancer components ( via increasing drug solubility ( Platinum precursors such as Pt () are applied to produce Pt () as a GSH-scavenging agent

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