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A crucial role of alogliptin in inflammation, oxidative stress, and kidney damage by modulating MAP3K/JNK/c-Jun and SMAD3 pathways was established [41]

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GLP-1 receptor agonists reduce energy intake by up to roughly 40%, according to a 2025 review of the evidence, and they do it through three overlapping pathways: appetite suppression, delayed gastric emptying, and altered nutrient absorption