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Depression, or major depressive disorder (MDD), is currently ranked third in the global burden of disease by the World Health Organisation and is projected to become the leading cause by 2030 [65]

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This elasticity improvement likely reflects both new elastin synthesis and better preservation of existing elastin through reduced oxidative damage and elastase inhibition

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Nonetheless, our peripheral GSH findings suggests that intracellular GSH may be more sensitive to early stages of disease and that extracellular changes become apparent in more severe stages of cognitive impairment such as AD