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Chronological (Intrinsic) Aging Intrinsic or chronological aging is a natural process with the passage of time that causes inflammation with the production of reactive oxygen species (ROS) resulting in oxidative stress from cellular metabolism, which results in a loss of skin homeostasis [9, 10, 14] (Fig

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[DOI] [PubMed] [Google Scholar] 71.Zavorsky G.S., Kubow S., Grey V., Riverin V., Lands L.C

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