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Based on the evidence from multi-center long-term cardiovascular outcome trials (CVOTs) which showed that GLP-1 RAs could reduce cardiovascular mortality and the incidence of non-fatal myocardial infarction or non-fatal stroke, GLP-1 RAs have been incorporated into clinical guidelines by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) [6,7,8,9,10]

This origin is why much of the initial and ongoing research has focused on its powerful protective and healing effects within the gastrointestinal system.

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GLP-1 Agonist Use and Side Effects in the United States ResearchPublished Aug 6, 2025 GLP-1 agonists are a class of medications that are prescribed to manage blood sugar for those with type 2 diabetes and to treat obesity