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L-glutathione is a natural tripeptide containing sulfur, formed by the amino acids Cysteine, Glycine and Glutamic acid
Excessive ROS levels can induce cellular damage, initiating a cascade of effects that potentially culminate in tissue and organ injury ( 3.1.1 Impact of ROS on cellular function and atherosclerosis Elevated ROS can induce endothelial cell dysfunction or death, disrupting the vascular barrier and leading to vasoconstrictive and vasodilatory dysfunction, vascular smooth muscle cell proliferation and migration, inflammatory responses, and thrombosisprocesses intimately associated with various cardiovascular disorders, including atherosclerosis, hypertension, and CHD ( in vivo ROS generation represents a promising therapeutic strategy for CHD treatment
doi: 10.1038/s41467-019-09277-9 49 KraftVANBezjianCTPfeifferSRingelstetterLMullerCZandkarimiFet al
To elucidate the effect of GCLC and glutathione loss on brain homeostasis, we biochemically and histochemically analyzed brain pathologies in neuronal GCLC-conditional knockout (GCLC floxed X CaMKII-Cre
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