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Hagemeier SR, Barlow EA, Meng Q, Kenney SC (2012) The cellular ataxia telangiectasia-mutated kinase promotes Epstein-Barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuli

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Consistent with this, following a meal the venous blood pyruvate/lactate exiting human muscle was 12% more reduced compared to the arterial blood pyruvate/lactate entering muscle, while during long-term fasting the venous blood pyruvate/lactate exiting muscle was 28% more reduced than the arterial blood entering (Aoki et al., 1975)

Both components are preclinical (animal/in-vitro)