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If you're pregnant, your needs go up to 2.6 micrograms a day, while you'll need 2.8 micrograms a day if you're breastfeeding, the organization says

Interestingly, GPx3 in epithelial vesicles may be of maternal origin, but GPx3 found in the basement membrane is of fetal origin, as GPx3 was absent in vesicles and present in the basement membrane in GPx3 fetuses from GPx3 knock-out females [81]

doi: 10.1210/en.2007-1227 219 KimHJMagraneJStarkovAAManfrediG

According to the Advisory Committee for Novel Foods (ACNF), there is currently a lack of robust safety assessment data on methylliberine, its effects on the human body, and its synergistic effect on the action of other stimulants, such as caffeine