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Clinical relevance of all these findings can be appreciated by studies showing association of hepatic DNA damage, increased expression of cell cycle inhibitors such as p21, and cell cycle arrest with impaired liver regeneration response in APAP-induced ALF patients [23,35]

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Encapsulation efficiency was measured using ICP-MS and revealed excellent encapsulation efficiency of DDA-GSH-AuNCs into PLGA matrix (93.09 1.71%), owing to the hydrophobic character of the nanoclusters that prevents its partition into the external polar phase (ethanol) and rather get encapsulated in the hydrophobic PLGA matrix

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