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10.1155/2019/7847142 8 CaoJ.WangH.ChenF.FangJ.XuA.XiW.et al (2016)
There is a great deal of evidence that a major pathogenic role in oxidative stress is played by transition metals, such as iron, copper and zinc, which catalyzes oxidation reactions also in the brain and their imbalance was frequently detected in brain tissue of AD patients thereby representing an interesting therapeutic target in AD treatment (Gutteridge, 1994
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Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis
PLoS One 9, e98467
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